Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG8)-MMAE bronic ester making it ideal for aqueous-based

making it ideal for aqueous-based applications without requiring organic solvents

including high photostability

https://clinicaltrials

SPAAC is copper-free

Product Name dCeMM1 Synonyms CAS Number 118719-16-7 Related CAS Molecular Formula C14H13BrN2O3S Molecular Weight 369

Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG8)-MMAE bronic ester making it ideal for aqueous-basedSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly